The effect of electrical stimulation of the hypothalamus on continuously-monitored blood glucose levels
Identifieur interne : 00E041 ( Main/Exploration ); précédent : 00E040; suivant : 00E042The effect of electrical stimulation of the hypothalamus on continuously-monitored blood glucose levels
Auteurs : D. M. Atrens [Australie] ; J. D. Sinden [France] ; L. Pénicaud [France] ; J. Louis-Sylvestre [France] ; J. Le Magnen [France]Source :
- Physiology & Behavior [ 0031-9384 ] ; 1984.
Descripteurs français
- Wicri :
- topic : Glucose.
English descriptors
- KwdEn :
- Academic press, Acrylic skull, Anaesthetised animals, Appropriate test, Atrens, Baseline blood glucose level, Blood glucose, Blood glucose levels, Body weight, Brain stimulation, Continuous blood glucose levels, Electrical stimulation, Electrode, Electrode locations, Electrode sites, Energy balance, Ethanol preference, Food intake, General disruption, Glucoregulatory parameters, Glucose, Glycemic, Glycemic change, Glycemic changes, Glycemic responses, Home cages, Hyper, Hyperglycemia, Hyperglycemic, Hyperglycemic response, Hypothalamic locations, Hypothalamic stimulation, Ingestive behaviour, Large effects, Large hyperglycemic response, Lateral, Lateral hypothalamus, Lateral sites, Lesion effects, Medial, Medial sites, Notation none, Overall summary, Physiol, Present experiment, Rat, Solid line, Standard error, Statistical significance, Stimulation, Stimulation charges, Stimulation effects, Test cage, Time course, Unanaesthetised animals, Unanaesthetised rats.
- Teeft :
- Academic press, Acrylic skull, Anaesthetised animals, Appropriate test, Atrens, Baseline blood glucose level, Blood glucose, Blood glucose levels, Body weight, Brain stimulation, Continuous blood glucose levels, Electrical stimulation, Electrode, Electrode locations, Electrode sites, Energy balance, Ethanol preference, Food intake, General disruption, Glucoregulatory parameters, Glucose, Glycemic, Glycemic change, Glycemic changes, Glycemic responses, Home cages, Hyper, Hyperglycemia, Hyperglycemic, Hyperglycemic response, Hypothalamic locations, Hypothalamic stimulation, Ingestive behaviour, Large effects, Large hyperglycemic response, Lateral, Lateral hypothalamus, Lateral sites, Lesion effects, Medial, Medial sites, Notation none, Overall summary, Physiol, Present experiment, Rat, Solid line, Standard error, Statistical significance, Stimulation, Stimulation charges, Stimulation effects, Test cage, Time course, Unanaesthetised animals, Unanaesthetised rats.
Abstract
Abstract: The effects of hypothalamic stimulation on blood glucose levels were investigated in unanaesthetised rats with intracardiac catheters directly connected to a continuous glucose analyzer. Thirty sec of low level electrical stimulation produced hyperglycemia at 23 of the 34 sites stimulated. At the remaining 11 sites the electrical stimulation produced no changes in blood glucose levels. The hyperglycemia could be dissociated from the changes in motor activity produced by the stimulation. The highest probability of producing hyperglycemia was found at ventro-lateral sites although hyperglycemia was also observed after stimulation of dorsal and medial sites. Apart from this medio-lateral difference in the density of sites at which stimulation produced hyperglycemia, the effects were not well differentiated anatomically. In addition, in terms of latency, peak magnitude and duration of the hyperglycemia, stimulation of the various hypothalamic subdivisions appeared to be functionally equivalent. Thus with respect to hypothalamic involvement in the maintenance of blood glucose levels the present stimulation analysis suggests a medio-lateral functional similarity which is very different from the medio-lateral reciprocity of lesion effects on ingestive behaviour and body weight.
Url:
DOI: 10.1016/0031-9384(84)90367-6
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: The effects of hypothalamic stimulation on blood glucose levels were investigated in unanaesthetised rats with intracardiac catheters directly connected to a continuous glucose analyzer. Thirty sec of low level electrical stimulation produced hyperglycemia at 23 of the 34 sites stimulated. At the remaining 11 sites the electrical stimulation produced no changes in blood glucose levels. The hyperglycemia could be dissociated from the changes in motor activity produced by the stimulation. The highest probability of producing hyperglycemia was found at ventro-lateral sites although hyperglycemia was also observed after stimulation of dorsal and medial sites. Apart from this medio-lateral difference in the density of sites at which stimulation produced hyperglycemia, the effects were not well differentiated anatomically. In addition, in terms of latency, peak magnitude and duration of the hyperglycemia, stimulation of the various hypothalamic subdivisions appeared to be functionally equivalent. Thus with respect to hypothalamic involvement in the maintenance of blood glucose levels the present stimulation analysis suggests a medio-lateral functional similarity which is very different from the medio-lateral reciprocity of lesion effects on ingestive behaviour and body weight.</div>
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